Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria.

@article{Ward2000PacemakingII,
  title={Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria.},
  author={Sean M Ward and Tamas Ordog and Sang Don Koh and Salah A Baker and Jae Yeoul Jun and Gustav Amberg and Kevin P. Monaghan and Kenton M. Sanders},
  journal={The Journal of physiology},
  year={2000},
  volume={525 Pt 2},
  pages={
          355-61
        }
}
Pacemaker cells, known as interstitial cells of Cajal (ICC), generate electrical rhythmicity in the gastrointestinal tract. Pacemaker currents in ICC result from the activation of a voltage-independent, non-selective cation conductance, but the timing mechanism responsible for periodic activation of the pacemaker current is unknown. Previous studies suggest that pacemaking in ICC is dependent upon metabolic activity 1y1yand1 Ca2+ release from intracellular stores. We tested the hypothesis that… CONTINUE READING
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