Pacemaker oscillations in heart and brain: a key role for hyperpolarization-activated cation channels.

@article{Gauss2000PacemakerOI,
  title={Pacemaker oscillations in heart and brain: a key role for hyperpolarization-activated cation channels.},
  author={Renate Gauss and Reinhard Seifert},
  journal={Chronobiology international},
  year={2000},
  volume={17 4},
  pages={453-69}
}
Rhythmic activity of single cells or multicellular networks is a common feature of all organisms. The oscillatory activity is characterized by time intervals of several seconds up to many hours. Cellular rhythms govern the beating of the heart, the swimming behavior of sperm, cycles of sleep and wakefulness, breathing, and the release of hormones. Many neurons in the brain and cardiac cells are characterized by endogenous rhythmic activity, which relies on a complex interplay between several… CONTINUE READING

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