Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop.

  title={Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop.},
  author={X. Wang},
  journal={Journal of neurophysiology},
  volume={87 2},
  • X. Wang
  • Published 2002
  • Medicine, Psychology
  • Journal of neurophysiology
  • Hippocampal theta (4-10 Hz) oscillation represents a well-known brain rhythm implicated in spatial cognition and memory processes. Its cellular mechanisms remain a matter of debate, and previous computational work has focused mostly on mechanisms intrinsic to the hippocampus. On the other hand, experimental data indicate that GABAergic cells in the medial septum play a pacemaker role for the theta rhythm. We have used biophysical modeling to address two major questions raised by the septal… CONTINUE READING
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