PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice.

@article{Shi2013PYY336AP,
  title={PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice.},
  author={Yan-chuan Shi and Zhou Lin and Jackie Lau and Hui Zhang and Miyuki Yagi and Isabella Kanzler and Amanda Sainsbury and Herbert Herzog and Shu Lin},
  journal={Obesity},
  year={2013},
  volume={21 12},
  pages={E669-78}
}
OBJECTIVE Peptide YY (PYY3-36) and pancreatic polypeptide (PP) potently inhibit food intake in rodents and humans, however, it is unclear whether they have any synergistic/additive interaction in decreasing food intake. DESIGN AND METHODS Fasted WT, Y2(-) (/) (-) , Y4(-) (/) (-) , or Y2Y4(-) (/) (-) mice were i.p. administrated with saline, PYY3-36, and/or PP. RESULTS Combined injection of PYY3-36 and PP reduces food intake in an additive manner was demonstrated in this study. This effect… CONTINUE READING