PYY-mediated fatty acid induced intestinal differentiation

  title={PYY-mediated fatty acid induced intestinal differentiation},
  author={Gregory W. Aponte},
  • G. Aponte
  • Published 1 February 2002
  • Biology
  • Peptides
Modulatory Role of PYY in Transport and Metabolism of Cholesterol in Intestinal Epithelial Cells
PYY is capable of influencing cholesterol homeostasis in intestinal Caco-2/15 cells depending on the site delivery and is able to decrease cholesterol uptake via NPC1L1 downregulation, whereas basolateral PYY diminished CM output through the biogenesis decline of apos B-48 and B-100.
Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche
The diverse roles of known niche cells in responding to gut microbiota and supporting IESCs are evaluated and the potential mechanisms by which microbiota may exert their influence on niche cells and possibly on IESC directly are discussed.
Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Evidence is presented on how gut microbiota interacts with intestinal chemosensing and modulates the release and activity of gut peptides, particularly GLP-1 and PYY, which contribute to body weight and energy homeostasis.
Gene expression in distal intestine of Atlantic salmon (Salmo salar L.) fed genetically modified soybean meal
Only minor differences in distal intestine transcriptional gene expression were observed between fish fed the diets with the non-GM and GM varieties.
Distal intestinal gene expression in Atlantic salmon (Salmo salar L.) fed genetically modified maize.
Only minor differences in DI transcriptional gene expression was observed between fish fed the GM and non-GM maize diets, and Expression of a clone showing high protein similarity to proton-dependent high-affinity oligopeptide transporter was significantly upregulated in fish-fed GM maize compared with fish- fed non- GM maize.
Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile.
Membrane Organization and Dynamics in Mammalian Sperm
This paper presents a meta-analyses of the determinants of Membrane properties and dynamics in sperm and their effects on capacitation and apoptosis.
Mice Lacking FABP9/PERF15 Develop Sperm Head Abnormalities but Are Fertile.
It is concluded that FABP9 plays only a minor role in providing the murine sperm head its characteristic shape and is not absolutely required for spermatogenesis or sperm function.


Expression of intestinal fatty acid binding protein in intestinal epithelial cell lines, hBRIE 380 cells.
The data show that I-FABP expression is limited to a differentiated population of hBRIE 380i cells and that the expression can be regulated by factors present in the extracellular matrix as well as involved in regulation of replication or metabolic state of the cell.
Regulation of gene expression by dietary fat.
The effects of fatty acids on the genome provide new insight into how dietary fat might play a role in health and disease.
Evidence for a Role of the Gut Hormone PYY in the Regulation of Intestinal Fatty Acid-binding Protein Transcripts in Differentiated Subpopulations of Intestinal Epithelial Cell Hybrids*
It is demonstrated that physiological concentrations of PYY can regulate I-FABP and place this peptide in a key position as part of a feedback system that determines the processing of cytosolic FFA in the enterocyte.
Fatty acid binding protein. Role in esterification of absorbed long chain fatty acid in rat intestine.
In everted gut sacs, inhibition of triglyceride synthesis by flavaspidic acid and alpha-bromopalmitate could not be explained as an effect on fatty acid uptake or on esterifying enzymes in the endoplasmic reticulum but rather can be interpreted as reflecting inhibition of fatty acid binding to FABP.
Cellular and molecular partners involved in gut morphogenesis and differentiation.
The role of basement membrane molecules, namely laminins, in the developmental and spatial epithelial behaviour; and the importance of the mesenchymal cell compartment in these processes are focused on.
Fatty acid transporters in animal cells.
  • T. Hui, D. Bernlohr
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 1997
Recent advances concerning the structure, function and regulation of putative fatty acid transporters are summarized.
Fatty acids in cell signalling: modulation by lipid binding proteins.
Evidence for transcriptional induction of the liver fatty-acid-binding-protein gene by bezafibrate in the small intestine.
The results demonstrate that the mouse terminal ileum is a useful system for studying the regulation of L-FABPc gene expression both in vivo and in vitro and indicate that the transcription of the L-fABpc gene is induced by bezafibrate via de novo protein synthesis and components of sunflower oil can transcriptionally activate the L.FABC gene.