PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.

@article{Wang2004PYNODAN,
  title={PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.},
  author={Yetao Wang and Mizuho Hasegawa and Ryu Imamura and Takeshi Kinoshita and Chiaki Kondo and Kenji Konaka and Takashi Suda},
  journal={International immunology},
  year={2004},
  volume={16 6},
  pages={777-86}
}
Recently, a large subfamily of nucleotide-binding and oligomerization domain-containing proteins that have an N-terminal pyrin-like domain and C-terminal leucine-rich repeats has been described. In this study, we identified PYNOD, a novel member of this family that lacks the leucine-rich repeats. We found that human PYNOD mRNA is expressed in various tissues and at high levels in heart, skeletal muscle and brain. It is also expressed in various cell lines, including haematopoietic cell lines… CONTINUE READING

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