PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition.

  title={PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition.},
  author={Nandini Verma and Omer Keinan and Michael Selitrennik and Thomas Karn and Martin Filipits and Sima Lev},
  journal={Nature communications},
Epithelial-to-mesenchymal transition (EMT) is a central developmental process implicated in cancer metastasis. Here we show that the tyrosine kinase PYK2 enhances cell migration and invasion and potentiates EMT in human breast carcinoma. EMT inducer, such as EGF, induces rapid phosphorylation of PYK2 and its translocation to early endosomes where it co-localizes with EGFR and sustains its downstream signals. Furthermore, PYK2 enhances EGF-induced STAT3-phosphorylation, while phospho-STAT3… CONTINUE READING
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