PYK 2 / PDZ-RhoGEF Links Ca 2 Signaling to RhoA

  title={PYK 2 / PDZ-RhoGEF Links Ca 2 Signaling to RhoA},
  author={Zhekang Ying and Fernanda Regina Giachini and Rita C A Tostes and Robert Clinton Webb},
Objective—Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA. Methods and Results—Adenoviral vectors were used to manipulate the expression of regulator of G protein signaling (RGS) domain containing Rho-specific guanine exchange factors (RhoGEFs) and proline-rich tyrosine kinase 2 (PYK2), a nonreceptor tyrosine kinase, in primary rat vascular smooth… CONTINUE READING
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