PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors.


The rapid development of drug resistance as a result of exposure to small molecule tyrosine kinase inhibitors (TKIs) is an important drawback to the successful use of these agents in the clinic. Although one of the most established mechanisms by which cells acquire drug resistance to anticancer drugs is the up regulation of drug efflux transporters such as… (More)
DOI: 10.1016/j.ejps.2012.12.019


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