PXR and CAR in energy metabolism

@article{Wada2009PXRAC,
  title={PXR and CAR in energy metabolism},
  author={T. Wada and Jie Gao and W. Xie},
  journal={Trends in Endocrinology & Metabolism},
  year={2009},
  volume={20},
  pages={273-279}
}
The nuclear receptors pregnane X receptor (PXR, or NR1I2) and constitutive androstane receptor (CAR, or NR1I3) were originally identified as xenosensors that regulate the expression of Phase I and Phase II drug-metabolizing enzymes and transporters. Recent results suggest that PXR and CAR also have important endobiotic roles in energy metabolism by affecting the metabolism of fatty acids, lipids and glucose. PXR and CAR exert their effects on energy metabolism through direct gene regulation or… Expand
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