PX- and FYVE-mediated interactions with membranes: simulation studies.

@article{Psachoulia2009PXAF,
  title={PX- and FYVE-mediated interactions with membranes: simulation studies.},
  author={Emi Psachoulia and Mark S. P. Sansom},
  journal={Biochemistry},
  year={2009},
  volume={48 23},
  pages={5090-5}
}
Molecular dynamics simulations have been used to explore the interactions of two PI(3)P-binding domains with their PI ligands and with a phospholipid bilayer. Three simulations each of the EEA1-FYVE domain and the p40(phox)-PX domain have been compared: with the protein in an apo state, with a bound Ins(1,3)P(2) molecule, and bound to a PI(3)P molecule embedded in a lipid bilayer. Two main questions were addressed in analysis of the simulations: (i) the location of these domains relative to the… CONTINUE READING