PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.

@article{Hayashi2007PXRICSAN,
  title={PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.},
  author={Tomoatsu Hayashi and Toshio Okabe and Yukiko Nasu-Nishimura and Fumika Sakaue and Susumu Ohwada and Ken Matsuura and Tetsu Akiyama and Tsutomu Nakamura},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2007},
  volume={12 8},
  pages={929-39}
}
In our previous study, we identified RICS, a novel beta-catenin-interacting protein with the GAP activity toward Cdc42 and Rac1, and found that RICS plays an important role in the regulation of neural functions, including postsynaptic NMDA signaling and neurite outgrowth. Here we report the characterization of an N-terminal splicing variant of RICS, termed PX-RICS, which has additional phox homology (PX) and src homology 3 (SH3) domains in its N-terminal region. The PX domain of PX-RICS… CONTINUE READING

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