PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice.

@article{Xue2012PVNAI,
  title={PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice.},
  author={Baojian Xue and Terry G. Beltz and Ralph F. Johnson and Fang Guo and Meredith Hay and Alan Kim Johnson},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 3},
  pages={H733-41}
}
Mineralocorticoid excess increases superoxide production by activating NADPH oxidase (NOX), and intracerebroventricular infusions of NADPH oxidase inhibitors attenuate aldosterone (Aldo)/salt-induced hypertension. It has been hypothesized that increased reactive oxygen species (ROS) in the brain may be a key mechanism in the development of hypertension. The present study investigated the brain regional specificity of NADPH oxidase and the role of NOX2 and NOX4 NADPH oxidase subunits in the… CONTINUE READING

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