PUVA inhibits DNA replication, but not gene transcription at nonlethal dosages.

@article{Lftl1998PUVAID,
  title={PUVA inhibits DNA replication, but not gene transcription at nonlethal dosages.},
  author={M L{\"u}ftl and Martin Roecken and Gerd Plewig and Klaus Degitz},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 3},
  pages={399-405}
}
The combination of psoralens and UVA radiation (PUVA photochemotherapy) is an established treatment for many skin disorders. UVA-induced psoralen-DNA interactions are assumed to contribute to the cutaneous anti-inflammatory and anti-proliferative effects of PUVA. PUVA-induced DNA modifications might interfere not only with DNA replication, but also with… CONTINUE READING