PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.

@article{Naudin2017PUMILIOFOXP1SD,
  title={PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.},
  author={C{\'e}cile Naudin and Aurore Hattabi and Fabio Michelet and Ayda Miri-Nezhad and Aissa Benyoucef and Francoise Pflumio and François Guillonneau and Serge Fichelson and Isabelle Vigon and Isabelle Dusanter-Fourt and Evelyne Lauret},
  journal={Blood},
  year={2017},
  volume={129 18},
  pages={2493-2506}
}
RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hematopoietic stem/progenitor cell (HSPC) proliferation and survival in vitro and in vivo upon reconstitution assays. Moreover, we found that PUM1/2… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
6 Citations
54 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…