PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.

  title={PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.},
  author={C{\'e}cile Naudin and Aurore Hattabi and Fabio Michelet and Ayda Miri-Nezhad and Aissa Benyoucef and Francoise Pflumio and François Guillonneau and Serge Fichelson and Isabelle Vigon and Isabelle Dusanter-Fourt and Evelyne Lauret},
  volume={129 18},
RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hematopoietic stem/progenitor cell (HSPC) proliferation and survival in vitro and in vivo upon reconstitution assays. Moreover, we found that PUM1/2… CONTINUE READING
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