PUMA mediates the apoptotic response to p53 in colorectal cancer cells.

@article{Yu2003PUMAMT,
  title={PUMA mediates the apoptotic response to p53 in colorectal cancer cells.},
  author={Jian-jun Yu and Zhenghe Wang and Kenneth W. Kinzler and Bert Vogelstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={
          1931-6
        }
}
Although several genes that might mediate p53-induced apoptosis have been proposed, none have previously been shown to play an essential role in this process through a rigorous gene disruption approach. We used a gene-targeting approach to evaluate p53-mediated death in human colorectal cancer cells. Expression of p53 in these cells induces growth arrest through transcriptional activation of the cyclin-dependent kinase inhibitor p21. If p21 is disrupted via gene targeting, the cells die through… CONTINUE READING

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