PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress.

@article{Nickson2007PUMAIC,
  title={PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress.},
  author={Philip Nickson and Ambrus Toth and Peter Erhardt},
  journal={Cardiovascular research},
  year={2007},
  volume={73 1},
  pages={48-56}
}
OBJECTIVE Puma (p53-upregulated modulator of apoptosis), a proapoptotic BH3-only member of the Bcl-2 protein family, has been implicated in the pathomechanism of several diseases, including cancer, AIDS, and ischemic brain disease. We have recently shown that Puma is required for cardiac cell death upon ischemia/reperfusion of mouse hearts. Since ischemia/reperfusion is also associated with endoplasmic reticulum (ER) stress, in the present study we investigated whether Puma contributes to the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

Puma, a critical mediator of cell death — one decade on from its discovery

Cellular & Molecular Biology Letters • 2012
View 4 Excerpts
Highly Influenced

PUMA, a potent killer with or without p53

Oncogene • 2008
View 4 Excerpts
Highly Influenced

An improved protocol for primary culture of cardiomyocyte from neonatal mice

In Vitro Cellular & Developmental Biology - Animal • 2007
View 4 Excerpts
Highly Influenced

Life, death, the unfolded protein response and apoptosis.

Cardiovascular research • 2007
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 33 references

p53 and stress in the ER.

Genes & development • 2004
View 11 Excerpts
Highly Influenced

Death begets failure in the heart.

The Journal of clinical investigation • 2005
View 8 Excerpts
Highly Influenced

Endoplasmic reticulum stress: cell life and death decisions.

The Journal of clinical investigation • 2005
View 13 Excerpts
Highly Influenced

Intracellular calcium release and cardiac disease.

Annual review of physiology • 2005
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…