PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis.

Abstract

The BCL-2 family of proteins regulates apoptosis by controlling mitochondrial outer membrane permeabilization (MOMP). Within the family there are numerous protein-protein interactions that influence MOMP; however, defining the ultimate signal that commits a cell to apoptosis remains controversial. We chose to examine the function of the BH3-only protein… (More)

Topics

  • Presentations referencing similar topics