PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer

@inproceedings{Thirukkumaran2017PUMAAN,
  title={PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer},
  author={Chandini M Thirukkumaran and Zhong-Qiao Shi and Ponnampalam Thirukkumaran and Joanne M. Luider and Karen A. Kopciuk and Jason C. L. Spurrell and Kate E. Elzinga and Don Morris},
  booktitle={PloS one},
  year={2017}
}
BACKGROUND AND PURPOSE Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven clinical activity, the underlying mechanisms of reovirus oncolysis is still not well elucidated. If reovirus therapy is to be optimized for cancer, including breast cancer patients, it is imperative to understand the… CONTINUE READING

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