PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

@article{Tunaru2003PUMAGAH,
  title={PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect},
  author={S. Tunaru and Jukka Kero and A. Schaub and Christian Wufka and A. Blaukat and K. Pfeffer and S. Offermanns},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={352-355}
}
  • S. Tunaru, Jukka Kero, +4 authors S. Offermanns
  • Published 2003
  • Biology, Medicine
  • Nature Medicine
  • Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue through a… CONTINUE READING

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    References

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