PUMA: a puzzle piece in chloroquine’s antimelanoma activity

@inproceedings{Amaravadi2013PUMAAP,
  title={PUMA: a puzzle piece in chloroquine’s antimelanoma activity},
  author={Ravi K Amaravadi},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
Chloroquine (CQ) can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. Although it is well known that CQ impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of CQ and the subsequent cascade of events that lead to cell death are not fully understood. Recent evidence… CONTINUE READING