PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation.

Abstract

AIM To investigate the function of PU.1-silenced semi-mature dendritic cells (DCs) and the possibility of utilizing cell immunity in rat intestinal transplantation. METHODS DCs were isolated from the bone marrow of F344 rats and cultured using the adherent method. The PU.1 gene was knocked down in DCs using small interfering RNAs (siRNAs) for 24 h, and… (More)
DOI: 10.3748/wjg.v19.i43.7766

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