PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection.

@article{Carey2007PU1RA,
  title={PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection.},
  author={Brenna C. Carey and Margaret K Staudt and Dana Bonaminio and Johannes Christiaan Maria van der Loo and Bruce C. Trapnell},
  journal={Journal of immunology},
  year={2007},
  volume={178 4},
  pages={2440-7}
}
Adenovirus is endocytosed and efficiently destroyed by human and murine alveolar macrophages (AMs) and rapidly cleared from the lungs of wild-type but not GM-CSF(-/-) mice. We hypothesized that GM-CSF may regulate adenovirus clearance in AMs via the transcription factor PU.1 by redirecting virion trafficking from the nucleus to lysosomes. This hypothesis… CONTINUE READING