PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation.

@article{Rekhtman2003PU1AP,
  title={PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation.},
  author={Natasha Rekhtman and Kevin S Choe and Igor Matushansky and Stuart Murray and Tom{\'a}s Stopka and Arthur I. Skoultchi},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 21},
  pages={7460-74}
}
PU.1 and GATA-1 are two hematopoietic specific transcription factors that play key roles in development of the myeloid and erythroid lineages, respectively. The two proteins bind to one another and inhibit each other's function in transcriptional activation and promotion of their respective differentiation programs. This mutual antagonism may be an important aspect of lineage commitment decisions. PU.1 can also act as an oncoprotein since deregulated expression of PU.1 in erythroid precursors… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Molecular ties between the cell cycle and differentiation in embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 2014

References

Publications referenced by this paper.
Showing 1-10 of 76 references

Similar Papers

Loading similar papers…