PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.

@article{Crotti2008PU1AN,
  title={PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.},
  author={Tania N. Crotti and Sudarshana M Sharma and Joseph D. Fleming and Merrilee R Flannery and Michael C. Ostrowski and Steven Robert Goldring and Kevin P. Mchugh},
  journal={Journal of cellular physiology},
  year={2008},
  volume={215 3},
  pages={636-44}
}
Expression of the alpha(v)beta(3) integrin is required for normal osteoclast function. We previously showed that an evolutionary conserved NFATc1 binding site is required for RANKL induction and NFATc1 transactivation of the human beta(3) promoter. The mechanism conferring specificity for RANKL induction and NFATc1 transduction of the beta(3) gene in… CONTINUE READING