PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity.

@article{Clech2006PU1Spi1BT,
  title={PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity.},
  author={Mika{\"e}l Le Clech and Elias Chalhoub and Christiane Dohet and Virginie Roure and Serge Fichelson and Françoise Moreau-Gachelin and Dani{\`e}le Mathieu},
  journal={Journal of molecular biology},
  year={2006},
  volume={355 1},
  pages={9-19}
}
The TAL-1/SCL gene encodes a basic helix-loop-helix (bHLH) transcription factor essential for primitive hematopoiesis and for adult erythroid and megakaryocytic development. Activated transcription of TAL-1 as a consequence of chromosomal rearrangements is associated with a high proportion of human T cell acute leukemias, showing that appropriate control of… CONTINUE READING