PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.

@article{Salustri2004PTX3PA,
  title={PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.},
  author={Antonietta Salustri and Cecilia Garlanda and Emilio Hirsch and Marika De Acetis and Alessia Maccagno and Barbara Bottazzi and Andrea Doni and Antonio Bastone and Giovanna Mantovani and Paolo Beck Peccoz and Giovanni Salvatori and David J. Mahoney and Anthony J Day and Gregorio Siracusa and Luigina Romani and Alberto Mantovani},
  journal={Development},
  year={2004},
  volume={131 7},
  pages={1577-86}
}
PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility. Here, we report that the infertility of Ptx3(-/-) mice is associated with severe abnormalities of the cumulus oophorus and failure of in vivo, but not in vitro, oocyte fertilization. PTX3 is produced by mouse cumulus cells during cumulus expansion and localizes in the matrix. PTX3 is expressed in the human cumulus oophorus as well. Cumuli from Ptx3(-/-) mice… CONTINUE READING
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