PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells

Abstract

Pituitary tumor transforming gene (PTTG) is a well-studied oncogene for its role in tumorigenesis and serves as a marker of malignancy in several cancer types including lung. In the present study, we defined the role of PTTG in actin cytoskeleton remodeling, cell migration and induction of epithelial mesenchymal transition (EMT) through the regulation of… (More)
DOI: 10.1038/onc.2011.488

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