PTPmu signaling via PKCdelta is instructive for retinal ganglion cell guidance.

@article{Ensslen2004PTPmuSV,
  title={PTPmu signaling via PKCdelta is instructive for retinal ganglion cell guidance.},
  author={Sonya E Ensslen and Susann M Brady-Kalnay},
  journal={Molecular and cellular neurosciences},
  year={2004},
  volume={25 4},
  pages={558-71}
}
The receptor protein tyrosine phosphatase (RPTP) PTPmu mediates distinct cellular responses in nasal and temporal retinal ganglion cell (RGC) axons. PTPmu is permissive for nasal RGC neurite outgrowth and inhibitory to temporal RGCs. In addition, PTPmu causes preferential temporal growth cone collapse. Previous studies demonstrated that PTPmu associates with the scaffolding protein RACK1 and the protein kinase C-delta (PKCdelta) isoform in chick retina and that PKCdelta activity is required for… CONTINUE READING