PTPN22 gene polymorphism in Takayasu's arteritis.

  title={PTPN22 gene polymorphism in Takayasu's arteritis.},
  author={Nil Sahin and Kenan Aksu and Sevil Kamal{\'i} and Muge Bicakcigil and Zeynep Ozbalkan and Izzet Fresko and Howard Ozer and Servet Akar and Ahmet Mesut Onat and Veli Çobankara and Sedat Kiraz and Mehmet Akif Ozt{\"u}rk and Ercan Tunç and Erinç Y{\"u}cel and Ask{\'y}n Ates and Gokhan Keser and Murat Inanç and Haner Direskeneli and G Saruhan-Direskeneli},
  volume={47 5},
OBJECTIVE Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. METHODS Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22… CONTINUE READING
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