PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.

@article{Maine2014PTPN22CT,
  title={PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.},
  author={Christian J. Maine and Kristi L. Marquardt and Jocelyn Cheung and Linda A Sherman},
  journal={Journal of immunology},
  year={2014},
  volume={192 4},
  pages={1415-24}
}
A single nucleotide polymorphism in PTPN22 (R620W), which encodes the Lyp tyrosine phosphatase, has been linked to a number of autoimmune diseases including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Studies in PTPN22 knockout (KO) mice and in mice expressing the mouse homolog of the pro-autoimmune allele, PEP(R619W), have reported increased germinal center activity and enhanced Ab production. In this article, we present findings that explain the basis for… CONTINUE READING
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