PTPN22 allele polymorphisms in 15 Chinese populations.

  title={PTPN22 allele polymorphisms in 15 Chinese populations.},
  author={Z-H Zhang and Feng Chen and X Zhang and Y. -T. Jin and Jing Bai and S B Fu},
  journal={International journal of immunogenetics},
  volume={35 6},
Protein tyrosine phosphatase non-receptor 22 (PTPN22) is involved in the negative regulation of T-cell responsiveness. Recently, it has been reported that a single nucleotide polymorphism (SNP), C1858T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), is associated with an increased risk of a number of autoimmune diseases. To study the mutant frequency and polymorphism of PTPN22 in Chinese populations, 1085 individuals from 15 Chinese populations… CONTINUE READING