PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.

@article{Ghorban2019PTPN221C,
  title={PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.},
  author={Khodayar Ghorban and Rana Ezzeddini and Majid Eslami and Bahman Yousefi and Bizhan Sadighi Moghaddam and Mohammad Taher Tahoori and Maryam Dadmanesh and Amir Salek Farrokhi},
  journal={Immunology letters},
  year={2019}
}
INTRODUCTION Rheumatoid arthritis (RA) is one of the most common prevalent autoimmune diseases. The 1858C/T (rs2476601) single nucleotide polymorphism (SNP) within the PTPN22 gene has been associated with susceptibility to inflammatory based diseases in several populations. It is implicated that altered cytokine production has a potential pathogenic role in the development of RA. The aim of this work was to analyze the association of 1858C/T PTPN22 polymorphism in RA patients with cytokine… 
Association of TNF-α Promoter Polymorphisms and Some Inflammatory Cytokines with Susceptibility to Rheumatoid Arthritis in Saudi Population
TLDR
TNF-α promoter 308 polymorphism GG genotype may be considered as a risk factor for RA and the TNF- α serum level was significantly related to the functional disability in the disease.
rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis—a possible interface?
TLDR
The thesis that genetic variations in PTPN22, PADI4, and CTLA4 genes may represent a possible link between PD and RA is supported.
The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis.
TLDR
A meta-analysis showed that the PTPN22 R620W polymorphism is associated with the risk of GD and HT in the overall study population, and the T allele significantly increased AITD susceptibility in all genetic models involving Caucasians, but not in Asians.
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with unexplained recurrent pregnancy loss: A case-control study
TLDR
The findings suggest that the PTPN22 1858T polymorphism could play a role in recurrent pregnancy loss and genotyping of the mentioned polymorphism can help clinicians to predict the probable risk of URPL.
PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta‐analysis
TLDR
A meta‐analysis was aimed to provide a solution for this issue and evaluated the role of protein tyrosine phosphatase non‐receptor 22 (PTPN22) gene rs2476601 single nucleotide polymorphism (SNP) in conferring a risk for RA.
Diagnostic value of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor in rheumatoid arthritis in Asia: a meta-analysis
TLDR
Anti-CCP and RF combined detection improves the diagnostic efficiency of RA, providing a potential strategy for early clinical screening in the Asian population.
Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
TLDR
The current knowledge about tyrosine phosphatases that regulate early TCR signaling is summarized and their involvement in autoimmunity and their potential as targets for tumor immunotherapy are discussed.

References

SHOWING 1-10 OF 55 REFERENCES
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population
TLDR
Findings provide further evidence that the PTPN22 gene may play an important role in the susceptibility to some autoimmune diseases, including RA, GD and T1D in Russian population.
Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.
TLDR
The previously reported association of PTPN22 with RF-positive RA was confirmed, which was independent from the HLA-DRB1 genotype, and no association between PTPn22 and the presence of the Hla-DR B1 shared epitope or clinical characteristics was found.
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
TLDR
This study replicated the findings of a previous association with RA and identified a novel association with JIA, providing further evidence that the PTPN22 gene plays a role in the pathogenesis of a subgroup of autoimmune diseases.
Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls
TLDR
In the Slovak population, HLA-DRB1 alleles as well as SNPs in STAT4 and PTPN22 genes showed a strong association with RA.
Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients
TLDR
The results provide further evidence that the PTPN22 1858T allele is associated with RA irrespective of autoantibody production and indicate that the genetic contribution to disease pathogenesis might be more prominent in men.
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases
TLDR
Evidence is provided of an association between autoimmune diseases and the 1858C>T polymorphism in PTPN22 and the increased risk in rheumatoid arthritis and coeliac disease.
PTPN22 1858C>T Polymorphism Distribution in Europe and Association with Rheumatoid Arthritis: Case-Control Study and Meta-Analysis
TLDR
A North-South gradient of the allele frequency seems to exist in Europe, with a lower prevalence of the mutation in the Mediterranean area, with the PTPN22 T1858 allele associated with RA in the Italian population.
The PTPN22 Locus and Rheumatoid Arthritis: No Evidence for an Effect on Risk Independent of Arg620Trp
TLDR
The Trp620 allotype of PTPN22 confers susceptibility to rheumatoid arthritis (RA) and certain other classical autoimmune diseases and there is no evidence for a common variant additional to rs2476601 within the PTPn22 locus that influences the risk of RA.
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
TLDR
The data reveal a lack of association between this variant and Crohn's disease, suggesting that the PTPN22 1858T allele is a risk allele for multiple, but not all, autoimmune diseases.
Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis.
TLDR
PTPN22 1858T, TNFRII 196R and HLA-SE alleles do not improve the predictive value of RF and ACPA for RA diagnosis in a cohort of patients with very early arthritis, and do not contribute to an earlier diagnosis in undifferentiated patients initially negative for RF andACPA.
...
1
2
3
4
5
...