PTPN14 is required for the density-dependent control of YAP1.

@article{Wang2012PTPN14IR,
  title={PTPN14 is required for the density-dependent control of YAP1.},
  author={Wenqi Wang and Jun Huang and Xin Wang and Jingsong Yuan and Xu Li and Lin Feng and Jae-Il Park and Junjie Chen},
  journal={Genes & development},
  year={2012},
  volume={26 17},
  pages={
          1959-71
        }
}
Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. PTPN14 interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. We showed that PTPN14 promotes the nucleus-to-cytoplasm translocation of YAP1 during contact inhibition and thus inhibits YAP1 transactivation activity. Interestingly, PTPN14 protein stability was positively controlled by cell density. We identified the CRL2(LRR1) (cullin2 RING ubiquitin ligase… CONTINUE READING
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