PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

  title={PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.},
  author={Anjali K. Nath and Justine H Ryu and Youngnam N. Jin and Lee D Roberts and Andr{\'e} Dejam and Robert E. Gerszten and Randall T. Peterson},
  journal={Cell reports},
Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely tuned to match changing energy requirements. To discover new pathways regulating glucose levels in vivo, we performed a large-scale chemical screen in live zebrafish and identified the small molecule alexidine as a potent glucose-lowering agent. We found that alexidine inhibits the PTEN-like… CONTINUE READING
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