PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ.

@article{Petri2011PTPIP51AP,
  title={PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ.},
  author={Meike Petri and Philipp-S Koch and Albrecht Stenzinger and Klaus Kuchelmeister and Ulf Nestler and Agnieszka Paradowska and Klaus Steger and Alexander Brobeil and Mathias Viard and Margit Wimmer},
  journal={Histology and histopathology},
  year={2011},
  volume={26 12},
  pages={1531-43}
}
Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumour. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an interaction partner of 14-3-3β, which correlates with the grade of malignancy in gliomas. In this study PTPIP51 and its interacting partners 14-3-3β, PTP1B, c-Src, Raf-1 as well as EGFR were investigated in human glioblastoma. Twenty glioblastoma samples were analyzed on transcriptional and translational level by immunohistochemistry, in… CONTINUE READING

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