PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.

@article{Carlucci2010PTPD1SR,
  title={PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.},
  author={Annalisa Carlucci and Monia Porpora and Corrado Garbi and Mario Galgani and Margherita Santoriello and Massimo Mascolo and Domenico di Lorenzo and Vincenzo Altieri and Maria Quarto and Luigi Maria Terracciano and Max E. Gottesman and Luigi Insabato and Antonio Feliciello},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 50},
  pages={39260-70}
}
PTPD1, a cytosolic non-receptor protein-tyrosine phosphatase, stimulates the Src-EGF transduction pathway. Localization of PTPD1 at actin cytoskeleton and adhesion sites is required for cell scattering and migration. Here, we show that during EGF stimulation, PTPD1 is rapidly recruited to endocytic vesicles containing the EGF receptor. Endosomal localization of PTPD1 is mediated by interaction with KIF16B, an endosomal kinesin that modulates receptor recycling at the plasma membrane. Silencing… CONTINUE READING