PTP1B promotes focal complex maturation, lamellar persistence and directional migration.

Abstract

Previous findings established that ER-bound PTP1B targets peripheral cell-matrix adhesions and positively regulates cell adhesion to fibronectin. Here we show that PTP1B enhances focal complex lifetime at the lamellipodium base, delaying their turnover and facilitating α-actinin incorporation. We demonstrate the presence of catalytic PTP1BD181A-α-actinin… (More)
DOI: 10.1242/jcs.118828

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