PTP1B inhibitory secondary metabolites from marine-derived fungal strains Penicillium spp. and Eurotium sp.

@article{Sohn2013PTP1BIS,
  title={PTP1B inhibitory secondary metabolites from marine-derived fungal strains Penicillium spp. and Eurotium sp.},
  author={Jae Hak Sohn and Yu-Ri Lee and Dong-Sung Lee and Youn Chul Kim and Hyuncheol Oh},
  journal={Journal of microbiology and biotechnology},
  year={2013},
  volume={23 9},
  pages={1206-11}
}
The selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity. In the course of screening for PTP1B inhibitory fungal metabolites, the organic extracts of several fungal species isolated from marine environments were found to exhibit significant inhibitory effects, and the bioassay… CONTINUE READING