PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

@article{GonzlezRodrguez2008PTP1BDI,
  title={PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.},
  author={Agueda Gonz{\'a}lez-Rodr{\'i}guez and Carmen Nevado and Fernando Escriv{\'a} and Giorgio Sesti and Cristina M. Rondinone and Manuel Benito and Angela M Valverde},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 2},
  pages={G338-47}
}
The contribution of the liver to glucose utilization is essential to maintain glucose homeostasis. Previous data from protein tyrosine phosphatase (PTP) 1B-deficient mice demonstrated that the liver is a major site for PTP1B action in the periphery. In this study, we have investigated the consequences of PTP1B deficiency in glucose uptake in hepatocytes from neonatal and adult mice. The lack of PTP1B increased basal glucose uptake in hepatocytes from neonatal (3-5 days old) but not adult (10-12… CONTINUE READING

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