PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation.

@article{Garton1994PTPPESTAP,
  title={PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation.},
  author={Andrew J. Garton and Nicholas K. Tonks},
  journal={The EMBO journal},
  year={1994},
  volume={13 16},
  pages={
          3763-71
        }
}
The protein tyrosine phosphatase PTP-PEST is an 88 kDa cytosolic enzyme which is ubiquitously expressed in mammalian tissues. We have expressed PTP-PEST using recombinant baculovirus, and purified the protein essentially to homogeneity in order to investigate phosphorylation as a potential mechanism of regulation of the enzyme. PTP-PEST is phosphorylated in vitro by both cyclic AMP-dependent protein kinase (PKA) and protein kinase C (PKC) at two major sites, which we have identified as Ser39… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED