PTP-1B is an essential positive regulator of platelet integrin signaling

  title={PTP-1B is an essential positive regulator of platelet integrin signaling},
  author={Elena G Arias-Salgado and Fawaz Gaj Haj and Christophe Dubois and Barry Moran and Ana Kasirer-Friede and Barbara C. Furie and Bruce Furie and Benjamin G Neel and Sanford J Shattil},
  journal={The Journal of Cell Biology},
  pages={837 - 845}
Outside-in integrin alphaIIbbeta3 signaling is required for normal platelet thrombus formation and is triggered by c-Src activation through an unknown mechanism. In this study, we demonstrate an essential role for protein-tyrosine phosphatase (PTP)-1B in this process. In resting platelets, c-Src forms a complex with alphaIIbbeta3 and Csk, which phosphorylates c-Src tyrosine 529 to maintain c-Src autoinhibition. Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3… CONTINUE READING


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Src kinase activation by a novel and direct interaction with the integrin cytoplasmic domain

  • E. G. Arias-Salgado, S. Lizano, S. Sarker, J. S. Brugge, M. H. Ginsberg, S. J. Shattil.
  • Proc. Natl. Acad. Sci. USA. 100:13298–13302.
  • 2003
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