PTOV1 antagonizes MED25 in RAR transcriptional activation.

  title={PTOV1 antagonizes MED25 in RAR transcriptional activation.},
  author={Hye-Sook Youn and U Park and Eun-Joo Kim and S J Um},
  journal={Biochemical and biophysical research communications},
  volume={404 1},
Retinoic acid (RA) plays a role in cancer therapy. However, its long-term treatment is hindered by the acquired resistance which is not fully understood. Our previous study indicated that the transcriptional activity of RA receptor (RAR) is enhanced by association of MED25 with CREB-binding protein (CBP) through the PTOV domain, which is also present in prostate tumor over-expressed protein 1 (PTOV1). Here, we show that MED25 and PTOV1 reciprocally regulate RAR transcriptional activity through… CONTINUE READING

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