PTK6 promotes hepatocellular carcinoma cell proliferation and invasion.

  title={PTK6 promotes hepatocellular carcinoma cell proliferation and invasion.},
  author={Xiaohong Chen and Bo Geun Song and Yuanlong Lin and Lijun Cao and Shiyan Feng and Lin Zhang and Fuxiang Wang},
  journal={American journal of translational research},
  volume={8 10},
Protein tyrosine kinase 6 (PTK6) is a nonreceptor tyrosine kinase that plays a crucial role in some tumors. However, the role of PTK6 is still unknown in hepatocellular carcinoma (HCC). In this study, we demonstrated that the PTK6 expression was upregulated in HCC tissues compared with adjacent normal tissues. Moreover, PTK6 was upregulated in the HCC cell lines (Bel7402, Hep3B, SMMC7721 and HepG2) compared with the normal liver epithelial cell line (THLE3). Ectopic expression of PTK6 promoted… CONTINUE READING

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