PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.

Abstract

ATG3 (autophagy-related 3) is an E2-like enzyme essential for autophagy; however, it is unknown whether it has an autophagy-independent function. Here, we report that ATG3 is a relatively stable protein in unstressed cells, but it is degraded in response to DNA-damaging agents such as etoposide or cisplatin. With mass spectrometry and a mutagenesis assay… (More)
DOI: 10.1080/15548627.2016.1272742

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@article{Ma2017PTK2mediatedDO, title={PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.}, author={Ke Ma and Wan Pei Cherylin Fu and Ming Feng Tang and Chaohua Zhang and Tianyun Hou and Ran Li and XiaoPeng Lu and Yanan Wang and Jingyi Zhou and Xue Li and Luyao Zhang and Lina Wang and Ying Zhao and Wei-Guo Zhu}, journal={Autophagy}, year={2017}, volume={13 3}, pages={579-591} }