PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

@article{Cho2007PTIPAW,
  title={PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.},
  author={Y. Cho and Teresa B. Hong and Sunhwa Hong and Hong Guo and Hong Yu and Doyeob Kim and Tad Guszczynski and Gregory R Dressler and Terry D. Copeland and Markus Kalkum and Kai Ge},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 28},
  pages={20395-406}
}
PTIP, a protein with tandem BRCT domains, has been implicated in DNA damage response. However, its normal cellular functions remain unclear. Here we show that while ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and… CONTINUE READING

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