PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling.

@article{Yamada2008PTHrPPM,
  title={PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling.},
  author={Tamaki Yamada and Masumi Tsuda and Yusuke Ohba and Hideaki Kawaguchi and Yasunori Totsuka and Masanobu Shindoh},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={368 3},
  pages={575-81}
}
Parathyroid hormone-related protein (PTHrP) is detected in many aggressive tumors and involved in malignant conversion; however, the underlying mechanism remains obscure. Here, we identified PTHrP as a mediator of epidermal growth factor receptor (EGFR) signaling to promote the malignancies of oral cancers. PTHrP mRNA was abundantly expressed in most of the quiescent oral cancer cells, and was significantly upregulated by EGF stimulation via ERK and p38 MAPK. PTHrP silencing by RNA interference… CONTINUE READING

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