PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands.

@article{Lewin2000PTHrPET,
  title={PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands.},
  author={Ewa Lewin and Yolanda Almad{\'e}n and Mariano Rodr{\'i}guez and Klaus Olgaard},
  journal={Kidney international},
  year={2000},
  volume={58 1},
  pages={71-81}
}
BACKGROUND The secretion of parathyroid hormone (PTH) from the parathyroid glands might be regulated by autocrine/paracrine factors, and a feedback regulatory mechanism of PTH on the secretion of PTH has been suggested. Because of the existence of a common receptor between PTH and PTH-related peptide (PTHrP), the aim of the present study was to examine the possible effects of PTHrP 1-40 and 1-86 on PTH secretion in rats. METHODS In vivo, the effect of PTHrP on Ca++-regulated PTH secretion was… CONTINUE READING

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