PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.

@article{Li2011PTHrPDB,
  title={PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.},
  author={Jiarong Li and Andrew C Karaplis and Dao Huang and Peter M Siegel and Anne Camirand and Xian Fang Yang and William J. Muller and Richard Kremer},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 12},
  pages={4655-69}
}
Parathyroid hormone-related protein (PTHrP) is a secreted factor expressed in almost all normal fetal and adult tissues. It is involved in a wide range of developmental and physiological processes, including serum calcium regulation. PTHrP is also associated with the progression of skeletal metastases, and its dysregulated expression in advanced cancers causes malignancy-associated hypercalcemia. Although PTHrP is frequently expressed by breast tumors and other solid cancers, its effects on… CONTINUE READING