PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

@article{Dhillon2013PTHenhancedSA,
  title={PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.},
  author={Robinder S. Dhillon and Chao Xie and Wakenda Tyler and Laura M Calvi and Hani A Awad and Michael J Zuscik and Regis J O'keefe and Edward M Schwarz},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2013},
  volume={28 3},
  pages={586-97}
}
Recombinant parathyroid hormone (rPTH) therapy has been evaluated for skeletal repair in animal studies and clinical trials based on its known anabolic effects, but its effects on angiogenesis and fibrosis remain poorly understood. We examined the effects of rPTH therapy on blood vessel formation and osseous integration in a murine femoral allograft model, which caused a significant increase in small vessel numbers, and decreased large vessel formation (p < 0.05). Histology showed that rPTH… CONTINUE READING
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